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Biotech Offers Reason for Others' Failed Trials of Potential Alzheimer's Disease Treatments
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This Canadian developer of therapeutics for neurodegenerative diseases bases its opinion, in part, on its own preclinical findings.

To successfully treat the root cause of Alzheimer's disease, therapeutics must selectively and precisely target the toxic oligomer of beta amyloid, ProMIS Neurosciences Inc. (PMN:TSX; ARFXF:OTCQB) stated in a news release, noting potential treatments for this indication are failing in the clinic because they do not do that.

The company reiterated this view after Roche Holding and AC Immune, on Jan. 30, 2019, stopped two late-stage clinical trials of crenezumab, which was being evaluated as a treatment for Alzheimer's disease. Crenezumab failed in Phase 3, ProMIS pointed out, because it was not selective enough in its binding to "multiple molecular species of amyloid beta."

"Traditional methods are unable to generate antibodies that bind the toxic oligomer because traditionally raised antibodies can't be tuned to a precise molecular species," ProMIS' Chief Scientific Officer Neil Cashman said in the release. "That's why we're seeing antiamyloid casualty after casualty in the clinic."

Cashman highlighted it would be wrong to conclude that these and other trials for Alzheimer's disease therapuetics fail because beta amyloid is not the correct target. The data show the target is the right one, and the proper takeaway is that only the toxic oligomer must be targeted, an outcome that requires extreme precision.

ProMIS contends its drug candidate PMN 310 and others in development can accomplish that. In preclinical studies, PMN310 "demonstrated a high degree of binding to toxic oligomers without binding to nontoxic forms of amyloid beta protein," noted the release.

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Disclosure:
1) Doresa Banning compiled this article for Streetwise Reports LLC and provides services to Streetwise reports as an independent contractor. She or members of her household own securities of the following companies mentioned in the article: None. She or members of her household are paid by the following companies mentioned in this article: None.
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5) From time to time, Streetwise Reports LLC and its directors, officers, employees or members of their families, as well as persons interviewed for articles and interviews on the site, may have a long or short position in securities mentioned. Directors, officers, employees or members of their immediate families are prohibited from making purchases and/or sales of those securities in the open market or otherwise from the time of the interview or the decision to write an article until three business days after the publication of the interview or article. The foregoing prohibition does not apply to articles that in substance only restate previously published company releases. As of the date of this article, officers and/or employees of Streetwise Reports LLC (including members of their household) own securities of ProMIS Neurosciences, a company mentioned in this article.




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